As the keeper of a small-- ahem, MooMoo -- I found this study of special interest: Small dogs the world over can all trace their ancestry back to the Middle East, where the first diminutive canines emerged more than 12,000 years ago. A new study, which appears in BMC Biology, focused on a single gene responsible for size in dogs. Researchers found that the version of the gene IGF1 that is a major determinant of small size in dogs probably originated as a result of domestication of the Middle Eastern gray wolf, which also happens to be smaller than many other wolves. In terms of which came first, big dogs or small dogs, the answer is now the former. "Archaeological studies suggest that ancient (dog) remains found in Belgium, Germany and Western Russia, which date to 13,000-31,000 years ago, were most similar in body size to the Great Dane, while those from the Middle East dating to about 12,000 years ago were most similar to a small terrier," lead author Melissa Gray told Disc